PS41. Hypermethylation of SLC6A4 promoter in psychiatric disorders suppresses its expression.

Bipolar disorder(BD) is major psychiatric disorder characterized by an alternating mood episode such as major depressive episode, hypomanic episode, and manic episode. There have been various genetic studies on BD and previous studies reported several candidate genes considered to be associated with BD. ANK3 has been suggested as a possible susceptible gene of BD. In present study, we investigated the association of ANK3 variants with BD in the Korean population. We selected rs1938526 and rs10994336 of ANK3 for the study according to previous results of studies. After data qualification process including purifying DNA from blood samples, a total of 287 BD patients and 340 healthy controls were left. We performed case-control association analysis and case-control haplotype analysis on 2 of ANK3 single nucleotide polymorphisms (SNPs). We found no significant association between BD and control from casecontrol association analysis. However, we found that rs1938526/ rs10994336 in ANK3 shows significant finding (overall P = 3.6 x 10–11; permutation P = 0) from case-control haplotype analysis. The result of this study suggests that rs1938526 and rs10994336 of ANK3 could be as possible susceptible gene for BD in Korean population from haplotype analysis, although no significant genetic association. More research is needed to investigate and reconfirm ANK3 as a susceptible gene for BD as shown in previous and present studies.